Fearon D T, Locksley R M
Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, UK.
Science. 1996 Apr 5;272(5258):50-3. doi: 10.1126/science.272.5258.50.
Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.
在适应性免疫反应缓慢且更具决定性地发展起来之前，固有免疫一直被认为仅提供快速但不完整的抗菌宿主防御。然而，固有免疫在决定适应性免疫系统对哪些抗原做出反应以及该反应的性质方面可能具有额外作用。了解其中涉及的分子和途径可能为感染性疾病和自身免疫性疾病创造新的治疗选择。
