Yamashita K, Takagi T
Department of Anatomy, School of Dentistry, University of Tokushima, Japan.
Acta Anat (Basel). 1992;145(4):406-11. doi: 10.1159/000147398.
Two types of adipose cells were found in the connective tissue on day 7 after bone matrix gelatin (BMG) implantation and an injection of bupivacaine: mature adipose cells with a large lipid droplet (2-140 microns) and immature adipose cells with many small lipid droplets (0.1-2 microns). On day 10 after BMG implantation, typical adipose tissue was observed near the implant. The immature adipose cells had small, spherical mitochondria, glycogen granules and cytoplasmic microvesicles, and they might differentiate from undifferentiated mesenchymal cells in the connective tissue or the peripheral cells around the vessels as a white adipose tissue. These findings suggest that the differentiation of adipose cells in the connective tissue near heterotopic bone formation might be induced not only by mechanical and/or bupivacaine injury, but also by some factor or factors of the BMG.
在植入骨基质明胶（BMG）并注射布比卡因7天后，在结缔组织中发现了两种类型的脂肪细胞：含有大脂滴（2 - 140微米）的成熟脂肪细胞和含有许多小脂滴（0.1 - 2微米）的未成熟脂肪细胞。在BMG植入10天后，在植入物附近观察到典型的脂肪组织。未成熟脂肪细胞具有小的球形线粒体、糖原颗粒和细胞质微泡，它们可能作为白色脂肪组织从结缔组织中的未分化间充质细胞或血管周围的外周细胞分化而来。这些发现表明，异位骨形成附近结缔组织中脂肪细胞的分化可能不仅由机械和/或布比卡因损伤诱导，还可能由BMG的某些因素诱导。
