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脱矿骨基质明胶植入部位钙化肌纤维的超微结构

Ultrastructure of calcified muscle fibres at the implantation site of demineralized bone matrix gelatin.

作者信息

Yamashita K, Takagi T

机构信息

Department of Anatomy, School of Dentistry, University of Tokushima, Japan.

出版信息

Int J Exp Pathol. 1993 Dec;74(6):547-52.

PMID:8292552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2002258/
Abstract

To clarify the mechanism of calcification during new bone formation induced by demineralized bone matrix gelatin (BMG), BMG was implanted into the skeletal muscle of Sprague-Dawley (SD) rats and histological changes were examined 1,2,3,5,7 and 10 days later. From day 2 after implantation, calcification was observed in muscle fibres near the implanted BMG. Calcification of the BMG ('acellular mineral deposition') was first seen on day 3 and in both, calcification increased. The calcification of muscle fibre was first seen in the sarcoplasmic reticulum (SR) and then in mitochondria or lipid droplet-like structures of satellite cells. The muscle mineral deposition occurred without osteogenic cells and matrix vesicles in the same way as 'acellular mineral deposition'.

摘要

为阐明脱矿骨基质明胶（BMG）诱导新骨形成过程中的钙化机制，将BMG植入Sprague-Dawley（SD）大鼠的骨骼肌中，并于1、2、3、5、7和10天后检查组织学变化。植入后第2天起，在植入的BMG附近的肌纤维中观察到钙化。BMG的钙化（“无细胞矿物质沉积”）于第3天首次出现，且两者的钙化均增加。肌纤维的钙化首先出现在肌浆网（SR）中，然后出现在卫星细胞的线粒体或脂滴样结构中。肌肉矿物质沉积的发生方式与“无细胞矿物质沉积”相同，不存在成骨细胞和基质小泡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/5bbd3b08519f/ijexpath00018-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/a0095640e2f9/ijexpath00018-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/21bf52d112be/ijexpath00018-0032-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/06e888d02696/ijexpath00018-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/d54d192d8b9f/ijexpath00018-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/da35160ce176/ijexpath00018-0034-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/b6786240c1a4/ijexpath00018-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/d27e30b880b9/ijexpath00018-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/5bbd3b08519f/ijexpath00018-0035-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/a0095640e2f9/ijexpath00018-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/21bf52d112be/ijexpath00018-0032-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/06e888d02696/ijexpath00018-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/d54d192d8b9f/ijexpath00018-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/da35160ce176/ijexpath00018-0034-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/b6786240c1a4/ijexpath00018-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/d27e30b880b9/ijexpath00018-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/2002258/5bbd3b08519f/ijexpath00018-0035-c.jpg

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本文引用的文献

1
EXPERIMENTAL INTRACELLULAR CALCIFICATION OF MUSCLE.
Clin Orthop Relat Res. 1965 Mar-Apr;39:213-31.
2
Calcium deposits and new bone formation in muscle in rabbits.
J Surg Res. 1961 Jul;1:132-41. doi: 10.1016/s0022-4804(61)80010-3.
3
The production of heterotopic calcification by certain chemical salts.某些化学盐类导致的异位钙化的产生。
J Pathol. 1980 May;131(1):21-33. doi: 10.1002/path.1711310103.
4
Pathogenesis of skeletal muscle necrosis induced by tarantula venom.
Exp Mol Pathol. 1983 Jun;38(3):283-96. doi: 10.1016/0014-4800(83)90069-2.
5
Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography.通过羟基磷灰石色谱法纯化牛骨形态发生蛋白。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):371-5. doi: 10.1073/pnas.81.2.371.
6
Skeletal muscle calcergy.骨骼肌钙能
J Pathol. 1982 May;137(1):1-12. doi: 10.1002/path.1711370102.
7
Vitamin E deficiency. A sequential light and electron microscopic study of skeletal muscle degeneration in weanling rabbits.维生素E缺乏症。对断奶家兔骨骼肌变性进行的连续光镜和电镜研究。
Am J Pathol. 1968 May;52(5):1067-79.
8
Bone: formation by autoinduction.骨：通过自诱导形成。
Science. 1965 Nov 12;150(3698):893-9. doi: 10.1126/science.150.3698.893.
9
An electron microscope study on experimental calcification of skeletal muscle.骨骼肌实验性钙化的电子显微镜研究。
Clin Orthop Relat Res. 1972;88:197-217. doi: 10.1097/00003086-197210000-00031.
10
Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography.通过肝素亲和层析法分离骨生成素，一种细胞外基质相关的骨诱导蛋白。
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7109-13. doi: 10.1073/pnas.84.20.7109.