Mahmoud F, Abul H, al Saleh Q, Hassab-el Naby H, Kajeji M, Haines D, Burleson J, Morgan G
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Sulaibekhat, Kuwait.
J Dermatol. 1999 Jul;26(7):428-33. doi: 10.1111/j.1346-8138.1999.tb02021.x.
Psoriasis is a chronic inflammatory skin disorder characterized clinically by maculopapular skin lesions and on the cellular level by increased T-lymphocyte activation in the peripheral blood and migration of activated T-lymphocyte into the lesions. The lymphocyte subpopulations in peripheral blood from 21 Kuwaiti patients showed elevated levels of the T-lymphocyte activation marker CD25, as well as increased expression of HLA-DR compared with a group of age and sex-matched controls, confirming published findings on psoriasis. In addition, there was a tendency towards a significant increase in the CD4+/CD45RO+ (memory cell) population that was also consistent with peripheral T-lymphocyte activation. Immunohistological studies showed a heavy infiltrate of all cell types into the lesional tissue including, as expected, activated T-lymphocytes. An unexpected finding was significantly higher levels of B-lymphocytes infiltrating the psoriatic lesions; they numerically exceeded the T-lymphocyte infiltrate. This has previously been reported only in cases of psoriasis with concurrent arthritis. None of the subjects had arthritis, suggesting an immunopathological variant of psoriasis possibly specific to this population group.
银屑病是一种慢性炎症性皮肤病，临床特征为斑丘疹性皮肤病变，细胞水平上表现为外周血中T淋巴细胞活化增加以及活化的T淋巴细胞迁移至病变部位。与一组年龄和性别匹配的对照组相比，21名科威特患者外周血中的淋巴细胞亚群显示T淋巴细胞活化标志物CD25水平升高，以及HLA-DR表达增加，证实了关于银屑病的已发表研究结果。此外，CD4+/CD45RO+（记忆细胞）群体有显著增加的趋势，这也与外周T淋巴细胞活化一致。免疫组织学研究显示所有细胞类型大量浸润病变组织，包括如预期的活化T淋巴细胞。一个意外发现是浸润银屑病病变的B淋巴细胞水平显著更高；其数量超过了T淋巴细胞浸润。此前仅在并发关节炎的银屑病病例中报道过这种情况。所有受试者均无关节炎，提示这可能是该人群特有的银屑病免疫病理变异型。
