Chu C C, Chen K C, Diau G Y
Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
J Urol. 1999 Sep;162(3 Pt 1):861-3. doi: 10.1097/00005392-199909010-00078.
We evaluate whether steroid application alone or retraction and hygiene are responsible for successful results in boys treated with topical steroids for phimosis.
A prospective study was performed, which included a control group of 42 patients with phimosis seen at our outpatient department from January to June 1997. During that time we trained the parent to retract and clean the foreskin only. From July 1997 to June 1998 topical steroid cream was prescribed in addition to retraction and hygiene in 276 boys with phimosis. All cases were divided into 3 subgroups of asymptomatic, symptomatic and buried penis.
The response rate was greater than 95% in patients who received topical steroid treatment in addition to improved hygiene. Only 13 boys (less than 5%) had no response to steroid treatment. Of the control patients 23 (55%) had no response to gentle retraction and personal hygiene. There was a significant difference (p<0.001) in response rate between the study and control groups. However, the subgroup with a buried penis responded poorly to steroid, retraction and hygiene treatment. There was significant difference (p<0.001) in response rate between the buried penis and other steroid groups but no significant difference (p>0.05) in the control group.
Phimosis is a physiological condition in neonates due to natural adhesion between the foreskin and the glans. Chronic infection due to poor hygiene is responsible for most cases of childhood phimosis. Circumcision is the traditional treatment of choice for phimosis or unretractable foreskin, although it is not always desired by parents or surgeons. Topical steroid cream is an easy, safe and nonsurgical alternative for phimosis. However, boys with a buried penis are not good candidates for steroid treatment.
我们评估单独应用类固醇激素,还是包皮退缩及卫生护理,对接受局部类固醇激素治疗的包茎男孩治疗成功与否起主要作用。
进行了一项前瞻性研究,其中包括一个对照组,该组由1997年1月至6月在我们门诊部就诊的42例包茎患者组成。在此期间,我们仅培训家长如何将包皮退缩并清洁。从1997年7月至1998年6月,除对276例包茎男孩进行包皮退缩及卫生护理外,还开具了局部类固醇激素乳膏。所有病例分为无症状、有症状和埋藏阴茎3个亚组。
除卫生状况改善外,接受局部类固醇激素治疗的患者有效率大于95%。只有13名男孩(不到5%)对类固醇激素治疗无反应。对照组中有23名患者(55%)对轻柔的包皮退缩和个人卫生护理无反应。研究组和对照组的有效率存在显著差异(p<0.001)。然而,埋藏阴茎亚组对类固醇激素、包皮退缩及卫生护理治疗反应较差。埋藏阴茎组与其他类固醇激素组的有效率存在显著差异(p<0.001),但对照组无显著差异(p>0.05)。
包茎在新生儿期是一种生理状况,是由于包皮与龟头之间自然粘连所致。卫生状况差导致的慢性感染是儿童期包茎的大多数病例的病因。包皮环切术是包茎或包皮不能上翻的传统治疗选择,尽管家长或外科医生并非总是希望采用。局部类固醇激素乳膏是治疗包茎的一种简便、安全的非手术替代方法。然而,埋藏阴茎的男孩不是类固醇激素治疗的合适人选。