Zampieri Nicola, Corroppolo Michele, Camoglio Francesco Saverio, Giacomello Luca, Ottolenghi Alberto
Department of Surgical Sciences, Pediatric Surgical Unit, University of Verona, Verona, Italy- Policlinico G.B.Rossi, piazzale Scuro n. 1-Verona.
J Pediatr. 2005 Nov;147(5):705-6. doi: 10.1016/j.jpeds.2005.07.017.
Phimosis has been defined as unretractable foreskin without adherences or a circular band of tight prepuce preventing full retraction. We suggested a new treatment protocol combining betamethasone with stretching exercises to reduce the number of patients requiring surgery for phimosis. Between January 2003 and September 2004, 247 boys aged 4 to 14 years (mean 7.6) were included in this consecutive, prospective, open study. Patients were treated with 0.05% betamethasone cream applied to the distal aspect of the prepuce twice daily for the first 15 days, then once daily for 15 more days. Preputial gymnastics started 1 week after topical application of betamethasone. Ninety-six percent of patients receiving 1 or more cycles of betamethasone showed complete resolution of phimosis. There was a significant difference (P < .001) in response rate between the study and control groups. Only 10 boys in the study group had no response to steroid and stretching. Treatment with topical steroids, combined with stretching exercises, is a suitable alternative to surgical correction (preputial plasty/circumcision).
包茎被定义为包皮无法上翻且无粘连,或存在一圈紧绷的包皮环阻碍完全上翻。我们提出了一种新的治疗方案,将倍他米松与拉伸练习相结合,以减少因包茎需要手术治疗的患者数量。在2003年1月至2004年9月期间,247名年龄在4至14岁(平均7.6岁)的男孩被纳入这项连续、前瞻性、开放性研究。患者在前15天每天两次在包皮远端涂抹0.05%倍他米松乳膏,然后再每天一次涂抹15天。在局部应用倍他米松1周后开始进行包皮体操。接受1个或更多周期倍他米松治疗的患者中,96%的包茎完全消退。研究组与对照组的有效率存在显著差异(P < 0.001)。研究组中只有10名男孩对类固醇和拉伸无反应。局部应用类固醇联合拉伸练习是手术矫正(包皮成形术/包皮环切术)的合适替代方法。