子宫内膜异位症中的肿瘤标志物。
Tumor markers in endometriosis.
作者信息
Abrão M S, Podgaec S, Pinotti J A, de Oliveira R M
机构信息
Department of Obstetrics and Gynecology, University of São Paulo, School of Medicine, Brazil.
出版信息
Int J Gynaecol Obstet. 1999 Jul;66(1):19-22. doi: 10.1016/s0020-7292(99)00046-6.
OBJECTIVES
The objective of the present study was to determine the concentrations of CA 125, CA 15-3, CA 19-9, carcioembryogenic antigen (CEA), alpha-fetoprotein (AFP) and beta-2 microglobulin (B2MG) in patients with pelvic endometriosis.
METHOD
Fifty women were divided into two groups: group A (control) had no endometriosis or other diseases, and group B consisted of 35 women with pelvic endometriosis. All women were submitted to serum determination of CA 125, CA 15-3, CA 19-9, CEA, AFP and B2MG. Samples were collected during the menstrual cycle and 1 week later.
RESULTS
Mean CA 125 concentrations were altered in patients with endometriosis, but all 50 patients studied presented normal CEA, AFP and B2MG concentrations. Small variations detected in CA 19-9 and CA 15-3 had no statistical significance.
CONCLUSION
CA 125 is the only important marker in the diagnosis of stages III/IV of endometriosis, especially when blood samples for its determination are obtained during the first 3 days of the menstrual cycle.
目的
本研究的目的是测定盆腔子宫内膜异位症患者血清中CA 125、CA 15 - 3、CA 19 - 9、癌胚抗原（CEA）、甲胎蛋白（AFP）和β2微球蛋白（B2MG）的浓度。
方法
50名女性被分为两组：A组（对照组）无子宫内膜异位症或其他疾病，B组由35名盆腔子宫内膜异位症患者组成。所有女性均接受血清CA 125、CA 15 - 3、CA 19 - 9、CEA、AFP和B2MG的测定。在月经周期期间及1周后采集样本。
结果
子宫内膜异位症患者的平均CA 125浓度发生改变，但所有50名研究对象的CEA、AFP和B2MG浓度均正常。CA 19 - 9和CA 15 - 3检测到的微小变化无统计学意义。
结论
CA 125是诊断子宫内膜异位症Ⅲ/Ⅳ期的唯一重要标志物，尤其是在月经周期的前3天采集用于测定的血样时。
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