Abrão M S, Podgaec S, Pinotti J A, de Oliveira R M
Department of Obstetrics and Gynecology, University of São Paulo, School of Medicine, Brazil.
Int J Gynaecol Obstet. 1999 Jul;66(1):19-22. doi: 10.1016/s0020-7292(99)00046-6.
The objective of the present study was to determine the concentrations of CA 125, CA 15-3, CA 19-9, carcioembryogenic antigen (CEA), alpha-fetoprotein (AFP) and beta-2 microglobulin (B2MG) in patients with pelvic endometriosis.
Fifty women were divided into two groups: group A (control) had no endometriosis or other diseases, and group B consisted of 35 women with pelvic endometriosis. All women were submitted to serum determination of CA 125, CA 15-3, CA 19-9, CEA, AFP and B2MG. Samples were collected during the menstrual cycle and 1 week later.
Mean CA 125 concentrations were altered in patients with endometriosis, but all 50 patients studied presented normal CEA, AFP and B2MG concentrations. Small variations detected in CA 19-9 and CA 15-3 had no statistical significance.
CA 125 is the only important marker in the diagnosis of stages III/IV of endometriosis, especially when blood samples for its determination are obtained during the first 3 days of the menstrual cycle.
本研究的目的是测定盆腔子宫内膜异位症患者血清中CA 125、CA 15 - 3、CA 19 - 9、癌胚抗原（CEA）、甲胎蛋白（AFP）和β2微球蛋白（B2MG）的浓度。
50名女性被分为两组：A组（对照组）无子宫内膜异位症或其他疾病，B组由35名盆腔子宫内膜异位症患者组成。所有女性均接受血清CA 125、CA 15 - 3、CA 19 - 9、CEA、AFP和B2MG的测定。在月经周期期间及1周后采集样本。
子宫内膜异位症患者的平均CA 125浓度发生改变，但所有50名研究对象的CEA、AFP和B2MG浓度均正常。CA 19 - 9和CA 15 - 3检测到的微小变化无统计学意义。
CA 125是诊断子宫内膜异位症Ⅲ/Ⅳ期的唯一重要标志物，尤其是在月经周期的前3天采集用于测定的血样时。
