Department of Obstetrics and Gynecology, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.
Arch Gynecol Obstet. 2014 Jul;290(1):75-82. doi: 10.1007/s00404-014-3163-2. Epub 2014 Feb 1.
Endometriosis is defined as the presence of endometrial glands and stroma in ectopic locations and may be associated with local and systemic inflammatory processes. Copeptin is elevated in acute and chronic inflammation conditions. The aim of the present study was to determine whether serum copeptin levels were altered in women with endometriosis and played a role in the pathophysiology of the disease.
A total of 86 women were recruited for this case-control study. 50 patients with surgically proven endometriosis were included, while 36 patients without endometriosis comprised the control group. Patients were classified as having minimal, mild, moderate and severe disease in accordance with American Society of Reproductive Medicine revised classification. Two subgroups were formed by combining patients with minimal and mild disease and with moderate and severe disease (Stage 1-2, stage 3-4; respectively). Levels of copeptin, tumor markers (CA-125, CA-19-9, CA-15-3) and C-reactive protein in serum were measured.
Serum copeptin, CA-125, CA-15-3 and CA-19-9 levels were higher in the endometriosis group (p: 0.002; 0.001; 0.017; 0.015; respectively). Copeptin and CA-19-9 levels were significantly higher in stage 3-4 group as compared to stage 1-2 group (p: 0.004; 0.036 respectively). Serum copeptin levels were positively correlated with stage of the disease and size of endometriomas. ROC analysis revealed that CA-125 had the highest AUC for predicting endometriosis (0.938; 95 % confidence interval 0.882-0.993; p: 0.001).
Serum copeptin levels were significantly higher in patients with endometriosis as compared to healthy controls. Moreover, severity of the disease was correlated with serum copeptin levels.
子宫内膜异位症定义为子宫内膜腺体和基质出现在异位部位，并可能与局部和全身炎症过程有关。copeptin 在急性和慢性炎症情况下升高。本研究旨在确定子宫内膜异位症患者的血清 copeptin 水平是否发生改变，并在疾病的病理生理中发挥作用。
本病例对照研究共招募了 86 名女性。纳入了 50 名经手术证实患有子宫内膜异位症的患者，而 36 名无子宫内膜异位症的患者为对照组。根据美国生殖医学协会修订的分类，患者被分为轻度、中度和重度疾病。将轻度和轻度疾病以及中度和重度疾病的患者合并为两个亚组（分别为 stage 1-2 和 stage 3-4）。测量血清中的 copeptin、肿瘤标志物（CA-125、CA-19-9、CA-15-3）和 C 反应蛋白水平。
子宫内膜异位症组血清 copeptin、CA-125、CA-15-3 和 CA-19-9 水平较高（p：0.002；0.001；0.017；0.015；分别）。与 stage 1-2 组相比，stage 3-4 组的 copeptin 和 CA-19-9 水平显著升高（p：0.004；0.036；分别）。血清 copeptin 水平与疾病的分期和内异症囊肿的大小呈正相关。ROC 分析显示，CA-125 预测子宫内膜异位症的 AUC 最高（0.938；95%置信区间 0.882-0.993；p：0.001）。
与健康对照组相比，子宫内膜异位症患者的血清 copeptin 水平显著升高。此外，疾病的严重程度与血清 copeptin 水平相关。
