Fischer M, Bormann G, Wohlrab J, Marsch W C
Klinik und Poliklinik für Hautkrankheiten der Martin Luther-Universität Halle-Wittenberg.
Hautarzt. 1999 Jul;50(7):507-10.
Although the aetiology of morphea often remains unknown, various precipitating causes have been identified. Morphea is a rare development following irradiation. We observed a circumscribed scleroderma 14 years after x-ray-radiotherapy following surgery of breast cancer. Furthermore multiple weeping papules occurred within the radiation area. A relapse of the breast cancer was ruled out by histological examination which displayed a transepidermal elimination of acid mucin. The irradiation had obviously induced different reactions of the dermal fibroblasts (radiodermatitis, morphea, mucin production).
虽然硬斑病的病因通常仍不明确,但已确定了各种诱发因素。硬斑病是放射治疗后罕见的并发症。我们观察到1例乳腺癌术后接受X线放疗14年后出现局限性硬皮病。此外,在放疗区域内出现了多个渗出性丘疹。组织学检查排除了乳腺癌复发,显示酸性黏蛋白经表皮排出。放疗明显诱发了真皮成纤维细胞的不同反应(放射性皮炎、硬斑病、黏蛋白生成)。