放射后硬斑病：病例报告及文献综述
Post-Irradiation Morphea: Case report and review of the literature.
作者信息
Alhathlool Ammar, Hein Rüdiger, Andres Christian, Ring Johannes, Eberlein Bernadette
机构信息
Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
出版信息
J Dermatol Case Rep. 2012 Sep 28;6(3):73-7. doi: 10.3315/jdcr.2012.1106.
Abstract
BACKGROUND
Post-irradiation morphea (PIM) is an entity documented in the literature although still not mentioned in most of the dermatological textbooks with a frequency approximately 2 out of every 1000 patients who received radiotherapy. Most of the cases are misdiagnosed as recurrent or metastatic carcinoma.
MAIN OBSERVATIONS
We report on a 64-year-old woman who was treated with radiotherapy for breast cancer. Two years and eight months after the first dose of radiotherapy, she developed localized morphea in the irradiated area.
CONCLUSION
We report on a new case with a literature review and discuss pathogenesis, treatment modalities and post irradiation subcutaneos reactions mimicking PIM. Around 54 cases of post-irradiation morphea (PIM) were identified in the literature.
摘要
背景
放射后硬斑病（PIM）是文献中记载的一种疾病，尽管在大多数皮肤病学教科书中仍未提及，其发病率约为每1000例接受放疗的患者中有2例。大多数病例被误诊为复发性或转移性癌。
主要观察结果
我们报告一名64岁接受乳腺癌放疗的女性。在首次放疗剂量后两年零八个月，她在放疗区域出现局限性硬斑病。
结论
我们报告一例新病例并进行文献复习，讨论其发病机制、治疗方式以及类似PIM的放疗后皮下反应。文献中已确认约54例放射后硬斑病（PIM）病例。
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