Gainsford T, Alexander W S
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Mol Biotechnol. 1999 Apr;11(2):149-58. doi: 10.1007/BF02915808.
The recent discovery of leptin as a major controller of appetite has led to a detailed analysis of its specific actions in this process as well as any potential role in the etiology of obesity. It has also emerged that leptin has a wider spectrum of biological activities and has been strongly implicated in fertility and reproduction. The structural similarity between leptin and its receptor and cytokine-receptor systems that control hemopoiesis has also prompted investigation of the potential for this hormone to influence blood cell formation. Recent studies have shown that the leptin receptor is expressed on a diverse range of hemopoietic cells. Leptin itself appears to enhance proliferation of hemopoietic cells in vitro, particularly in combination with other cytokines and may augment some mature hemopoietic cell functions. Although only relatively minor hemopoietic deficiencies have been reported in mice lacking leptin or its receptor, these emerging studies suggest that further analysis of leptin actions in hemopoiesis may be warranted.
最近发现瘦素是食欲的主要调控因子，这促使人们对其在此过程中的具体作用以及在肥胖病因学中的任何潜在作用进行详细分析。还发现瘦素具有更广泛的生物活性，并与生育和繁殖密切相关。瘦素与其受体以及控制造血的细胞因子受体系统之间的结构相似性，也促使人们研究这种激素影响血细胞生成的可能性。最近的研究表明，瘦素受体在多种造血细胞上表达。瘦素本身似乎能在体外增强造血细胞的增殖，特别是与其他细胞因子联合使用时，并且可能增强一些成熟造血细胞的功能。尽管在缺乏瘦素或其受体的小鼠中仅报道了相对轻微的造血缺陷，但这些新出现的研究表明，可能有必要进一步分析瘦素在造血过程中的作用。
