Considine R V, Caro J F
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
Int J Biochem Cell Biol. 1997 Nov;29(11):1255-72. doi: 10.1016/s1357-2725(97)00050-2.
Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings will be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition.
瘦素作为一种新发现的代谢激素及其在治疗人类肥胖症方面的潜在治疗用途受到了广泛关注。此外，导致动物模型肥胖的瘦素信号通路缺陷增加了人类肥胖症病因相似的可能性。本综述将总结目前关于人类和啮齿动物瘦素的研究结果。将结合我们对瘦素介导的体重和成分调节的生理学及病理生理学可能性的观点来讨论这些发现。
