蛋白质缺乏与补充对实验动物细胞介导免疫的影响。
Effects of protein depletion and repletion on cell-mediated immunity in experimental animals.
作者信息
Daly J M, Dudrick S J, Copeland E M
出版信息
Ann Surg. 1978 Dec;188(6):791-6. doi: 10.1097/00000658-197812000-00013.
Abstract
Protein-calorie malnutrition leads to depression of host cell-mediated immunity. Nutritional repletion initially results in rapid weight gain followed by a more gradual return of immunocompetence. Administration of a synthetic amino acid diet to normal animals did not preserve body weight or cell-mediated immunity any better than did a high carbohydrate, protein-free diet. Administration of a synthetic amino acid diet to malnourished animals maintained body weight, but did not restore immunocompetence. Proper nutritional repletion should provide both adequate protein and nonprotein calories if a return of immunocompetence is to be anticipated.
摘要
蛋白质 - 热量营养不良会导致宿主细胞介导的免疫功能下降。营养补充最初会导致体重迅速增加，随后免疫能力会更逐渐恢复。给正常动物喂食合成氨基酸饮食，在维持体重或细胞介导免疫方面，并不比高碳水化合物、无蛋白饮食更好。给营养不良的动物喂食合成氨基酸饮食能维持体重，但不能恢复免疫能力。如果期望免疫能力恢复，适当的营养补充应同时提供足够的蛋白质和非蛋白质热量。
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