Jose D G, Good R A
J Exp Med. 1973 Jan 1;137(1):1-9. doi: 10.1084/jem.137.1.1.
Mice were fed diets deficient in a single essential amino acid, and the primary immune responses to inoculation of allogenic tumor cells was measured by in vitro assay of cellular immunity. Moderate reduction of the amino acids phenylalanine-tyrosine, valine, threonine, methionine-cystine, isoleucine, and tryptophane in the diet produced profound depression of hemagglutinating and blocking antibody responses, although cytotoxic cell-mediated immunity remained intact. These diets had previously been shown to result in a selective depression of tumor growth in mice. Limitation of the amino acids arginine, histidine, and lysine in the diets gave rise to only slight depression of the immune responses. These diets had previously been shown to produce a proportional decrease in both tumor growth and host body weight. Moderate leucine restriction resulted in a paradoxical depression of cytotoxic cell-mediated immunity with little effect on serum blocking activity. Slight increases had previously been noted in the weight of tumors in mice fed leucine-restricted diets. Deficiency or imbalance of essential amino acids in the diet may produce profound depression of immune responses and apparent, marked changes in the immune resistance of the host animal to tumors.
给小鼠喂食缺乏单一必需氨基酸的饮食，通过细胞免疫的体外测定来测量对同种异体肿瘤细胞接种的主要免疫反应。饮食中苯丙氨酸 - 酪氨酸、缬氨酸、苏氨酸、蛋氨酸 - 胱氨酸、异亮氨酸和色氨酸适度减少，会导致血凝和阻断抗体反应显著降低，尽管细胞毒性细胞介导的免疫仍保持完整。这些饮食此前已被证明会导致小鼠肿瘤生长选择性降低。饮食中限制精氨酸、组氨酸和赖氨酸只会使免疫反应略有降低。这些饮食此前已被证明会使肿瘤生长和宿主体重成比例下降。适度限制亮氨酸会导致细胞毒性细胞介导的免疫出现反常降低，而对血清阻断活性影响很小。此前已注意到，喂食亮氨酸限制饮食的小鼠肿瘤重量略有增加。饮食中必需氨基酸的缺乏或失衡可能会导致免疫反应显著降低，以及宿主动物对肿瘤的免疫抵抗力出现明显的显著变化。
