Abeles V, Harrus S, Angles J M, Shalev G, Aizenberg I, Peres Y, Aroch I
Department of Clinical Sciences, School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Vet Rec. 1999 Jul 31;145(5):130-4. doi: 10.1136/vr.145.5.130.
Six weimaraner puppies, five of which were genetically related, showed systemic signs associated with hypertrophic osteodystrophy, including fever and involvement of the gastrointestinal, respiratory or nervous systems, in addition to the metaphyseal lesions. In five of the dogs the clinical signs developed less than 10 days after they had been vaccinated with a modified live virus vaccine. Radiographic findings suggested that both the hindlimbs and forelimbs were equally involved in the disease process. Abnormal haematological findings included leucocytosis with neutrophilia and monocytosis, and there was a consistent increase in the activity of alkaline phosphatase. Serum protein electrophoretic studies of three of the dogs revealed hypogammaglobulinaemia and abetaglobulinaemia in two of them. Conservative treatment with rest and non-steroidal anti-inflammatory drugs had little effect, and treatment with corticosteroids appeared to give the best results.
6只魏玛犬幼犬，其中5只具有遗传相关性，除干骺端病变外，还出现了与肥厚性骨营养不良相关的全身症状，包括发热以及胃肠道、呼吸系统或神经系统受累。在5只犬中，临床症状在接种减毒活疫苗后不到10天就出现了。放射学检查结果表明，后肢和前肢在疾病过程中同样受累。血液学异常表现包括白细胞增多伴中性粒细胞增多和单核细胞增多，碱性磷酸酶活性持续升高。对其中3只犬进行的血清蛋白电泳研究显示，其中2只犬出现低丙种球蛋白血症和β球蛋白血症。采用休息和非甾体抗炎药的保守治疗效果甚微，而使用皮质类固醇治疗似乎效果最佳。
