Woodard J C
Vet Pathol. 1982 Jul;19(4):337-54. doi: 10.1177/030098588201900401.
All members of a weimaraner litter had clinical and radiographic signs of hypertrophic osteodystrophy shortly after weaning. Three dogs were necropsied. Radiographic metaphyseal densities, which are used to make a clinical diagnosis of hypertrophic osteodystrophy, were found to result from elongation of the calcified cartilage lattice of the primary spongiosa. Intertrabecular acute inflammation was associated with necrosis, failure to deposit osseous tissue on the calcified-cartilage lattice, and trabecular microfractures. This process led to metaphyseal infraction and separation of the epiphysis. Defective bone formation (osteodystrophy) was considered a secondary process resulting from inflammation of osteochondral complexes, marrow, and periosteum. Enamel hypoplasia also was found to be associated with inflammation of the dental crypt, and abnormal enamel matrix was observed in the developing teeth. The histopathology of the bones and teeth was different from alterations which occur in infantile scurvy or congenital syphilis, although these diseases of man have radiographic similarities to canine hypertrophic osteodystrophy. Because the radiologic lesion is nonspecific, a clinical diagnosis of hypertrophic osteodystrophy is not necessarily diagnostic of a specific disease due to a single etiologic agent. Liver levels of ascorbic acid were within the normal range. Although an infectious agent could not be identified, the conditions may have an infectious origin with systemic manifestations.
一窝魏玛犬在断奶后不久均出现了肥大性骨营养不良的临床和放射学症状。对三只犬进行了尸检。用于肥大性骨营养不良临床诊断的放射学干骺端密度，被发现是由于初级海绵骨钙化软骨晶格的延长所致。小梁间急性炎症与坏死、未能在钙化软骨晶格上沉积骨组织以及小梁微骨折相关。这一过程导致干骺端骨折和骨骺分离。骨形成缺陷（骨营养不良）被认为是骨软骨复合体、骨髓和骨膜炎症导致的继发过程。还发现釉质发育不全与牙囊炎症相关，并且在发育中的牙齿中观察到了异常的釉质基质。尽管人类的这些疾病在放射学上与犬肥大性骨营养不良有相似之处，但其骨骼和牙齿的组织病理学与婴儿坏血病或先天性梅毒所发生的改变不同。由于放射学病变不具有特异性，肥大性骨营养不良的临床诊断不一定能诊断出由单一病因引起的特定疾病。肝脏中的抗坏血酸水平在正常范围内。尽管无法确定感染因子，但这些情况可能起源于感染并伴有全身表现。
