Rosen T, Unkefer R P
Baylor College of Medicine, Houston, Texas, USA.
Cutis. 1999 Aug;64(2):107-9.
The explosive onset of fluctuant facial papulonodules, usually in young women, is characteristic of pyoderma faciale. This disorder is neither a true pyoderma nor a variant of acne, but rather a severe form of rosacea. The most effective therapeutic modality appears to be isotretinoin, especially if preceded by a brief course of oral corticosteroids or a short interval of application of potent topical corticosteroids. Despite our concern about the potential adverse effects of systemic retinoids on underlying inflammatory bowel disease, isotretinoin was given to a patient with refractory pyoderma faciale. Response was dramatic, and no ill effects were encountered.
波动性面部丘疹结节的急性发作，通常见于年轻女性，是面部脓皮病的特征。这种疾病既不是真正的脓皮病，也不是痤疮的变种，而是酒渣鼻的一种严重形式。最有效的治疗方式似乎是异维甲酸，尤其是在之前先进行一个短期的口服皮质类固醇疗程或短时间应用强效外用皮质类固醇之后。尽管我们担心全身性维甲酸对潜在的炎症性肠病有潜在不良反应，但仍给一位难治性面部脓皮病患者使用了异维甲酸。反应显著，且未出现不良影响。
