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[克罗恩病中的暴发性酒渣鼻、脓性口腔炎和脓性外阴炎:氨苯砜在联合治疗中的关键作用]

[Rosacea fulminans, pyostomatitis and pyovulvitis in Crohn's disease: dapsone as key factor in combination therapy].

作者信息

Gatzka M, Simon M, Schuler G, Lüftl M

机构信息

Hautklinik, Universitätsklinikum Erlangen, Germany.

出版信息

Hautarzt. 2006 Oct;57(10):898-902. doi: 10.1007/s00105-005-1017-3.

Abstract

Rosacea fulminans (also known as pyoderma faciale) has been reported to occur in association with Crohn's disease. It is still unclear whether the papulopustules and confluent nodules of rosacea fulminans represent a manifestation of mucocutaneous Crohn's disease or whether this association is a mere coincidence. A 46-year-old woman presented with the spontaneous outbreak of rosacea fulminans and pyostomatitis/pyovulvitis. Complete remission of the mucocutaneous symptoms was achieved with 2 months combination therapy with methylprednisolone, isotretinoin and dapsone. The patient's Crohn's disease, already diagnosed for 3 years, did not flare during this period.

摘要

暴发性酒渣鼻(也称为面部脓皮病)据报道与克罗恩病相关。目前仍不清楚暴发性酒渣鼻的丘疹脓疱和融合性结节是否代表黏膜皮肤型克罗恩病的一种表现,或者这种关联仅仅是巧合。一名46岁女性出现了暴发性酒渣鼻及脓性口炎/脓性外阴炎的自发发作。通过甲基泼尼松龙、异维A酸和氨苯砜联合治疗2个月,黏膜皮肤症状完全缓解。该患者已确诊克罗恩病3年,在此期间病情未发作。

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