Ciarrocca K N, Greenberg M S
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Aug;88(2):159-63. doi: 10.1016/s1079-2104(99)70110-1.
The purpose of this retrospective study was to investigate the efficacy of dapsone therapy in the management of mucous membrane pemphigoid.
The charts of 29 patients who had been diagnosed with mucous membrane pemphigoid by means of routine histologic analysis and direct immunofluorescence were reviewed. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of 4 groups according to his or her response to therapy.
Nine patients were treated successfully with topical corticosteroids alone. Eleven patients with moderate to severe disease who were treated initially with topical steroids showed minimal improvement; after dapsone was added, 7 of the 11 had total resolution of their lesions and 4 had greater than 75% improvement. Two patients had to discontinue dapsone because of side effects.
In this group of 20 patients with moderate to severe mucous membrane pemphigoid, the use of dapsone in combination with topical corticosteroids caused greater than 75% resolution of oral lesions in all patients studied.
本回顾性研究旨在探讨氨苯砜治疗黏膜类天疱疮的疗效。
回顾了29例经常规组织学分析和直接免疫荧光诊断为黏膜类天疱疮患者的病历。根据疾病严重程度将口腔症状分为1至3级。根据患者对治疗的反应将其分为4组。
9例患者仅外用糖皮质激素治疗成功。11例中度至重度疾病患者最初外用糖皮质激素治疗改善甚微；加用氨苯砜后，11例中有7例皮损完全消退，4例改善超过75%。2例患者因副作用不得不停用氨苯砜。
在这组20例中度至重度黏膜类天疱疮患者中，氨苯砜联合外用糖皮质激素使所有研究患者的口腔损害消退超过75%。
