Barber M D, Powell J J, Lynch S F, Gough N J, Fearon K C, Ross J A
University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.
Clin Exp Immunol. 1999 Sep;117(3):425-9. doi: 10.1046/j.1365-2249.1999.01005.x.
Polymorphisms of the tumour necrosis factor (TNF) gene have been related to TNF production and outcome in a variety of inflammatory and malignant diseases. Proinflammatory cytokines and the inflammatory state appear to affect outcome in pancreatic cancer. Thus, the present study examined the TNFB and TNF-308 polymorphisms for their relationship to the inflammatory state and survival in pancreatic cancer. Sixty-four patients with advanced pancreatic cancer and 101 healthy subjects were genotyped for each polymorphism. Serum concentrations of the two TNF receptors and C-reactive protein (CRP) were measured in 45 of the cancer patients with no evidence of infection or jaundice, 1 month after surgical intervention. There was no difference in distribution of genotypes between the patient and control groups. There was no association between any genotype and concentrations of any of the measured inflammatory mediators. While those with an elevated CRP concentration had significantly poorer survival, there was no association between either TNF genotype and survival. This study found no association between TNF genotype and the inflammatory state or survival in advanced pancreatic cancer. Other cytokines may be more important than TNF in determining the inflammatory state and disease progress in pancreatic cancer.
肿瘤坏死因子（TNF）基因多态性与多种炎症性疾病和恶性疾病中的TNF产生及预后相关。促炎细胞因子和炎症状态似乎会影响胰腺癌的预后。因此，本研究检测了TNFB和TNF - 308多态性与胰腺癌炎症状态及生存的关系。对64例晚期胰腺癌患者和101名健康受试者进行了各多态性的基因分型。在45例无感染或黄疸证据的癌症患者手术干预1个月后，检测了两种TNF受体和C反应蛋白（CRP）的血清浓度。患者组和对照组之间基因型分布无差异。任何基因型与任何测量的炎症介质浓度之间均无关联。虽然CRP浓度升高者的生存率明显较差，但两种TNF基因型与生存率之间均无关联。本研究发现TNF基因型与晚期胰腺癌的炎症状态或生存无关联。在决定胰腺癌的炎症状态和疾病进展方面，其他细胞因子可能比TNF更重要。
