Reichenbach J, Schubert R, Schwan C, Müller K, Böhles H J, Zielen S
Department of Paediatrics, Rheinische Friedrich-Wilhelms Universität, Bonn, Germany.
Clin Exp Immunol. 1999 Sep;117(3):535-9. doi: 10.1046/j.1365-2249.1999.01000.x.
Highly reactive oxygen species (ROS) are involved in T-cell activation and in the defense against environmental pathogens. An imbalance of ROS generation and detoxifying scavenger enzymes could contribute to the increased susceptibility to cancer and infections in ataxia telangiectasia. We studied oxidative status, i.e. plasma total antioxidant capacity (TEAC), retinol, alpha-tocopherol, ubiquinol, and the number of activated T cells in 10 patients with ataxia telangiectasia (AT) compared to age-matched healthy controls. As expected, patients showed significantly increased levels of activated human leukocyte antigen-DR and CD45RO expressing T cells. TEAC levels as well as the exogenous antioxidants retinol and alpha-tocopherol were significantly reduced in patients. In addition, patients showed slightly reduced plasma levels of the endogenous ROS scavenger enzyme ubiquinol (Q10). Although no correlation between number of activated T-cells and antioxidant capacity could be demonstrated, an increase in ROS and a diminished reactive oxygen scavenger capacity may be involved in the disease process of patients with AT.
高活性氧物种（ROS）参与T细胞活化以及抵御环境病原体。ROS生成与解毒清除酶之间的失衡可能导致共济失调毛细血管扩张症患者患癌症和感染的易感性增加。我们研究了10例共济失调毛细血管扩张症（AT）患者与年龄匹配的健康对照者的氧化状态，即血浆总抗氧化能力（TEAC）、视黄醇、α-生育酚、泛醇以及活化T细胞数量。正如预期的那样，患者中表达人类白细胞抗原-DR和CD45RO的活化T细胞水平显著升高。患者的TEAC水平以及外源性抗氧化剂视黄醇和α-生育酚显著降低。此外，患者血浆中内源性ROS清除酶泛醇（Q10）水平略有降低。虽然活化T细胞数量与抗氧化能力之间未显示出相关性，但ROS增加和活性氧清除能力减弱可能参与了AT患者的疾病进程。
