Berman B, Flores F
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33136, USA.
Dermatol Surg. 1999 Jun;25(6):484-6. doi: 10.1046/j.1524-4725.1999.08292.x.
The exact mechanisms of action responsible for the effectiveness of silicone gel dressings are unknown, although it has been proposed that static electricity generated by friction could be the reason for their anti-scarring effects.
We compared the efficacy of a cushion of silicone filled with liquid silicone gel reported to induce greater negative static-electric charge with silicone gel sheeting in the treatment of hypertrophic and keloid scars.
The size, volume, symptoms (tenderness and itching), and signs (color and induration) of hypertrophic (10 patients) or keloid scars (22 patients) were measured at baseline at 16 weeks following use of either the silicone gel cushion or silicone gel sheeting, as determined by random assignment.
Both the silicone gel cushion and the silicone gel sheeting treatments were effective in decreasing scar volume, 53.0% and 36.3%, respectively. The percentages of keloids and hypertrophic scars benefiting from the silicone cushion and the silicone sheeting were similar with respect to reduction in tenderness (36.3% vs 33.3%), itching (45.5% vs 33.3%), and redness (0.1% vs 0.1%), and in the degree of softening (45.5 vs 25.0%).
Both the silicone gel cushion and the silicone gel sheeting treatments were effective in the treatment of keloids and hypertrophic scars, although no statistically significant differences were found between the two treatment modalities.
尽管有人提出摩擦产生的静电可能是硅凝胶敷料产生抗瘢痕效果的原因,但其确切作用机制尚不清楚。
我们比较了据报道能产生更大负静电荷的填充液体硅凝胶的硅胶垫与硅凝胶片在治疗增生性瘢痕和瘢痕疙瘩方面的疗效。
根据随机分配情况,在使用硅胶垫或硅凝胶片16周后的基线期,测量增生性瘢痕(10例患者)或瘢痕疙瘩(22例患者)的大小、体积、症状(压痛和瘙痒)及体征(颜色和硬结)。
硅胶垫和硅凝胶片治疗均能有效减少瘢痕体积,分别为53.0%和36.3%。在压痛减轻(36.3%对33.3%)、瘙痒减轻(45.5%对33.3%)、发红减轻(0.1%对0.1%)以及软化程度(45.5对25.0)方面,从硅胶垫和硅凝胶片治疗中获益的瘢痕疙瘩和增生性瘢痕的比例相似。
硅胶垫和硅凝胶片治疗在瘢痕疙瘩和增生性瘢痕的治疗中均有效,尽管两种治疗方式之间未发现统计学上的显著差异。