Paolisso G, Tagliamonte M R, Rizzo M R, Giugliano D
Department of Geriatric Medicine and Metabolic Diseases - II University of Naples, Italy.
Eur J Clin Invest. 1999 Sep;29(9):758-69. doi: 10.1046/j.1365-2362.1999.00522.x.
The relationship between advancing age and insulin resistance is widely known, but the cause(s) of such association are less well understood. Age-related changes in anthropometric characteristics and environmental factors (changes in diet habits and decline in physical activity) have been hypothesized as being among the main causes. More recently, the role of plasma insulin-like growth factor I (IGF-I), dehydroepiandrosterone sulphate (DHEAS) and tumour necrosis factor alpha (TNF-alpha) concentrations as well as the degree of oxidative stress have also been evaluated. As far as the anthropometric changes are concerned, a decline in fat-free mass and a relative or absolute increase in fat mass are common findings in aged subjects. Such changes are combined with a decline in plasma DHEAS and IGF-I concentration and a rise in plasma TNF-alpha concentrations and oxidative stress, which, in turn, may interact with the anthropometric changes determining the worsening in insulin-mediated glucose uptake. Finally, age-related environmental factors (changes in diet quality and decline in the degree of physical activity) might be a common factor allowing anthropometric factors and age-related remodelling to accelerate their negative impact on insulin action.
衰老与胰岛素抵抗之间的关系广为人知，但这种关联的原因却鲜为人知。人体测量特征和环境因素（饮食习惯的改变和体力活动的减少）的年龄相关变化被认为是主要原因之一。最近，血浆胰岛素样生长因子I（IGF-I）、硫酸脱氢表雄酮（DHEAS）和肿瘤坏死因子α（TNF-α）浓度以及氧化应激程度的作用也得到了评估。就人体测量变化而言，无脂肪量的减少和脂肪量的相对或绝对增加是老年受试者的常见现象。这些变化与血浆DHEAS和IGF-I浓度的下降以及血浆TNF-α浓度和氧化应激的升高相结合，反过来，这可能与人体测量变化相互作用，从而导致胰岛素介导的葡萄糖摄取恶化。最后，与年龄相关的环境因素（饮食质量的变化和体力活动程度的下降）可能是一个共同因素，使得人体测量因素和与年龄相关的重塑加速对胰岛素作用产生负面影响。
