Amir J, Harel L, Smetana Z, Varsano I
Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva.
Pediatr Dermatol. 1999 Jul-Aug;16(4):259-63. doi: 10.1046/j.1525-1470.1999.00072.x.
Herpetic gingivostomatitis is the most common specific clinical manifestation of primary herpes simplex infection in childhood. The aim of the present study was to describe the clinical signs, symptoms, viral shedding, serologic findings, and complications in community-acquired gingivostomatitis. We prospectively followed children with herpes simplex type 1 gingivostomatitis lasting less than 72 hours. Clinical examination and viral culture were repeated every 2 to 3 days as long as symptoms or signs persisted. Thirty-six children (ages 12-77 months) were included in the study. Mean duration of oral lesions was 12.0+/-3.4 days; extraoral lesions (in 26 children), 12.0 +/-3.9 days; fever, 4.4+/-2.4 days; and eating/drinking difficulties, 9.1+/-3.0 and 7.1+/-3.1 days, respectively. In all children, viral cultures of the oral lesions were positive for herpes simplex virus (HSV) type 1; viral shedding persisted for a mean of 7.1+/-2.5 days (range 2-12 days). The main complications were dehydration, with three children hospitalized for intravenous rehydration, and one case of secondary bacteremia. Herpetic gingivostomatitis is a relatively severe manifestation of primary HSV type 1 infection in young children.
疱疹性龈口炎是儿童原发性单纯疱疹感染最常见的特异性临床表现。本研究的目的是描述社区获得性龈口炎的临床体征、症状、病毒排出、血清学检查结果及并发症。我们对1型单纯疱疹性龈口炎病程持续时间不到72小时的儿童进行了前瞻性随访。只要症状或体征持续存在，每2至3天重复进行临床检查和病毒培养。36名儿童（年龄12至77个月）纳入本研究。口腔损害的平均持续时间为12.0±3.4天；口外损害（26名儿童）为12.0±3.9天；发热为4.4±2.4天；进食/饮水困难分别为9.1±3.0天和7.1±3.1天。所有儿童口腔损害的病毒培养均显示1型单纯疱疹病毒（HSV）阳性；病毒排出持续时间平均为7.1±2.5天（范围2至12天）。主要并发症为脱水，3名儿童因静脉补液住院治疗，1例发生继发性菌血症。疱疹性龈口炎是幼儿原发性1型HSV感染的一种相对严重的表现形式。
