Kanazawa Y, Kuramata T
Jpn J Antibiot. 1976 Apr;29(4):366-76.
Drug-sensitivity of 70 strains of Y. enterocolitica and 24 of Y. pseudotuberculosis including reference strains and isolates from men or animals were determined by the agar plate-dilution method. All the strains of Y. enterocolitica were relatively resistant to penicillins and cephalosporins, while all of Y. pseudotuberculosis were sensitive to both of the agents. Most of the strains of both species excluding 13 resistant ones were sensitive to streptomycin. The resistant strains, however, were sensitive to other aminoglycoside antibiotics, i.e. kanamycin, paromomycin, gentamicin, tobramycin, dibekacin and amikacin. All of the strains were sensitive to chloramphenicol. Most of the strains excluding 3 resistant ones were highly sensitive to tetracycline. The resistant strains were also resistant to doxycycline and methacycline but not to minocycline. All of them were resistant to erythromycin, to lincomycin and to novobiocin. Most of them excluding 7 resistant strains were sensitive to sulfisoxazole. All of them were sensitive to nalidixic acid, piromidic acid, and also to dihydroxymethylfuratrizine. A new synthetic agent, fosfomycin showed a relatively wide range of activity to the strains, but none of resistant strains were noticed. These resistant strains were all found in the isolates from men and animals but not in reference strains. Among these resistant strains, resistance patterns were as follows; TC, SM, SA in 3 of Y. enterocolitica, SM, SA in 3 of Y. enterocolitica and in 1 of Y. pseudotuberculosis, and SM in 3 of the both species, respectively. As for polypeptide antibiotics, polymyxin B and colistin, some strains of the both species showed an uncontinous susceptibility, i.e. inhibited growth at a certain lower concentration but growth at a higher concentration.
采用琼脂平板稀释法测定了70株小肠结肠炎耶尔森菌和24株假结核耶尔森菌（包括参考菌株以及来自人和动物的分离株）的药敏情况。所有小肠结肠炎耶尔森菌菌株对青霉素和头孢菌素相对耐药，而所有假结核耶尔森菌菌株对这两种药物均敏感。除13株耐药菌株外，两种菌的大多数菌株对链霉素敏感。然而，这些耐药菌株对其他氨基糖苷类抗生素敏感，即卡那霉素、巴龙霉素、庆大霉素、妥布霉素、地贝卡星和阿米卡星。所有菌株对氯霉素敏感。除3株耐药菌株外，大多数菌株对四环素高度敏感。这些耐药菌株对多西环素和甲烯土霉素也耐药，但对米诺环素不耐药。所有菌株对红霉素、林可霉素和新生霉素均耐药。除7株耐药菌株外，大多数菌株对磺胺异恶唑敏感。所有菌株对萘啶酸、吡咯酸以及二羟甲基呋喃三嗪均敏感。一种新型合成药物磷霉素对这些菌株显示出相对广泛的活性，但未发现耐药菌株。这些耐药菌株均在人和动物的分离株中发现，而参考菌株中未发现。在这些耐药菌株中，耐药模式如下：小肠结肠炎耶尔森菌3株为四环素、链霉素、琥珀酸；小肠结肠炎耶尔森菌3株和假结核耶尔森菌1株为链霉素、琥珀酸；两种菌各3株为链霉素。至于多肽抗生素多粘菌素B和黏菌素，两种菌的一些菌株表现出不连续的敏感性，即在一定较低浓度下生长受到抑制，但在较高浓度下生长。
