Kanazawa Y, Kuramata T
Jpn J Antibiot. 1975 Aug;28(4):538-41.
Seven strains of Y. enterocolitica, of which 2 strains being resistant to SM, TC and SA, 2 to SM and SA 3 to SM, and 3 strains of Y. pseudotuberculosis resistant to SM have been isolated from men and domestic animals. Tests were carried out with these 10 isolates for transfer of the drug resistance by bacterial conjugation, and evidence was obtained for transfer of resistance from 1 SM-resistant Y. enterocolitica and 2 Y. pseudotuberculosis strains to the sensitive E. coli K-12. Moreover, secondary transfer of this resistance to sensitive strains of the donor species Y. enterocolitica and Y pseudotuberculosis was also demonstrated. The findings indicate the spontaneous occurrence of organisms carrying the resistance transfer factor, R(Sm), among the populations of these two species in the natural environment.
从人和家畜中分离出7株小肠结肠炎耶尔森菌,其中2株对链霉素(SM)、四环素(TC)和磺胺异恶唑(SA)耐药,2株对SM和SA耐药,3株对SM耐药;还分离出3株对SM耐药的假结核耶尔森菌。对这10株分离菌进行了细菌接合转移耐药性试验,结果表明,1株耐SM的小肠结肠炎耶尔森菌和2株假结核耶尔森菌可将耐药性转移至敏感的大肠杆菌K-12。此外,还证明了这种耐药性可再次转移至供体菌小肠结肠炎耶尔森菌和假结核耶尔森菌的敏感菌株。这些发现表明,在自然环境中,这两个菌种的菌群中会自发出现携带耐药转移因子R(Sm)的生物体。