Gaye O, Soumaré M, Sambou B, Faye O, Dieng Y, Diouf M, Bah I B, Dieng T, N'dir O, Diallo S
Service de parasitologie, Faculté de médecine, UCAD, Dakar, Sénégal.
Bull Soc Pathol Exot. 1999 Jul;92(3):149-52.
In order to evaluate the in vivo efficacy of chloroquine in the treatment of P. falciparum malaria, studies have been carried out in Richard-Toll, Fatick and Tambacounda, 3 areas where dynamics of transmission, population movements, as well as prophylactic and curative practises are different. Failure rates in treatment were 13% in site 1 (Richard-Toll) where medical pressure and population movements are high. In sites 2 and 3 (Fatick and Tambacounda), the failure rate was 3%. Even if medical pressure is lower in the latter site (Tambacounda), the higher transmission could be a factor in the spreading of resistance. A surveillance system and better use of chloroquine must be undertaken.
为了评估氯喹治疗恶性疟原虫疟疾的体内疗效，已在理查德 - 托尔、法蒂克和坦巴昆达开展了研究，这三个地区的传播动态、人口流动以及预防和治疗措施各不相同。在医疗压力和人口流动较大的1号地点（理查德 - 托尔），治疗失败率为13%。在2号和3号地点（法蒂克和坦巴昆达），失败率为3%。即使后一个地点（坦巴昆达）的医疗压力较低，但较高的传播率可能是耐药性传播的一个因素。必须建立监测系统并更好地使用氯喹。
