Navarro J, Maldonado J, Narbona E, Ruiz-Bravo A, García Salmerón J L, Molina J A, Gil A
Department of Microbiology, University of Granada, Spain.
Biofactors. 1999;10(1):67-76. doi: 10.1002/biof.5520100108.
We examined the effects of nucleotide supplementation to a preterm adapted milk formula on the lymphocyte subsets and plasma IgG, IgM and IgA levels in preterm infants for the first three months of life. Two groups of preterm infants received a milk formula or the same formula supplemented with CMP, AMP, UMP, GMP and IMP to mimic the concentration of acid-soluble nucleotides found in human milk. Blood samples were obtained at birth, 10 days, 20-30 days and 3 months of age. Preterm infants fed the nucleotide formula exhibited higher plasma levels of IgM in all postnatal study periods than neonates fed the standard formula; moreover, IgA was also higher at 3 months of age in nucleotide formula fed infants. No major differences were seen between groups for IgG levels and lymphocyte subsets. Thus, dietary nucleotides appear to exert actions on immature human neonate lymphocytes enhancing the in vivo production of Ig which may have a role in the defense capacity of neonates.
我们研究了在早产适应奶粉中添加核苷酸对早产婴儿出生后前三个月淋巴细胞亚群以及血浆IgG、IgM和IgA水平的影响。两组早产婴儿分别接受一种奶粉或添加了胞嘧啶核苷酸（CMP）、腺嘌呤核苷酸（AMP）、尿嘧啶核苷酸（UMP）、鸟嘌呤核苷酸（GMP）和次黄嘌呤核苷酸（IMP）的相同奶粉，以模拟母乳中酸溶性核苷酸的浓度。在出生时、出生后10天、20 - 30天以及3个月时采集血样。在所有产后研究阶段，喂食核苷酸奶粉的早产婴儿血浆IgM水平均高于喂食标准奶粉的新生儿；此外，喂食核苷酸奶粉的婴儿在3个月大时IgA水平也更高。两组在IgG水平和淋巴细胞亚群方面未观察到重大差异。因此，膳食核苷酸似乎对未成熟的人类新生儿淋巴细胞有作用，可增强体内Ig的产生，这可能在新生儿的防御能力中发挥作用。
