Griener E D, Dahan E, Lambert S R
Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
J Cataract Refract Surg. 1999 Sep;25(9):1209-13. doi: 10.1016/s0886-3350(99)00158-3.
To determine whether removal of the crystalline lens and placement of an intraocular lens (IOL) in human infant eyes retard the growth of the pseudophakic eye.
A unilateral lensectomy with placement of a posterior chamber IOL in the sulcus was performed in 11 infants between 2 and 4 months of age. Axial length measurements of both eyes were obtained preoperatively and postoperatively.
Patients were followed for a mean of 5.6 years. In 7 patients, the mean axial growth was 0.46 mm less in the pseudophakic eye than in the fellow eye (range 0.15 to 0.70 mm). In 1 patient, there was no interocular axial length difference and in 3, the pseudophakic eye was longer. When measurements from the only patient with microphthalmia were excluded, the interocular difference in axial growth was highly significant (signed rank test, P = .006). Median visual acuity of the pseudophakic eyes at the last follow-up was 20/60 (range 20/30 to 20/200). The final visual acuity in the pseudophakic eyes did not correlate with the degree of interocular axial length difference (P > .05).
Our study suggests there may be a reduction in axial growth in infantile eyes following cataract extraction and IOL implantation. This effect probably reduces the magnitude of the myopic shift in these eyes.
确定在人类婴儿眼中摘除晶状体并植入人工晶状体（IOL）是否会延缓假晶状体眼的生长。
对11例2至4个月大的婴儿进行了单侧晶状体切除术，并将后房型人工晶状体植入睫状沟。术前和术后均对双眼进行眼轴长度测量。
患者平均随访5.6年。7例患者中，假晶状体眼的平均眼轴生长比健眼少0.46毫米（范围为0.15至0.70毫米）。1例患者双眼眼轴长度无差异，3例患者假晶状体眼更长。排除仅有的1例小眼球患者的测量数据后，眼轴生长的眼间差异具有高度显著性（符号秩检验，P = 0.006）。最后一次随访时假晶状体眼的中位视力为20/60（范围为20/30至20/200）。假晶状体眼的最终视力与眼间眼轴长度差异程度无关（P>0.05）。
我们的研究表明，婴儿白内障摘除和人工晶状体植入术后眼轴生长可能会减少。这种效应可能会降低这些眼睛近视性屈光不正的程度。
