Foley J E, Crawford-Miksza L, Dumler J S, Glaser C, Chae J S, Yeh E, Schnurr D, Hood R, Hunter W, Madigan J E
School of Veterinary Medicine, Department of Medicine and Epidemiology, University of California, Davis 95616, USA.
Clin Infect Dis. 1999 Aug;29(2):388-92. doi: 10.1086/520220.
We report two cases of human granulocytic ehrlichiosis (HGE) that occurred in northern California in summer 1998. Patients had fever, malaise, and myalgia, reported tick bites, had moderate thrombocytopenia, and had normal or slightly elevated liver enzyme activities. Ehrlichial inclusions were observed in the blood of one patient, and HGE-agent DNA was amplified by PCR from both patients. Genetically, the strains resembled horse isolates from northern California. The close spatial and temporal proximity of the two new cases may be due to a nidus of infection in the area or heightened surveillance by local physicians.
我们报告了1998年夏季在加利福尼亚州北部发生的两例人粒细胞埃立克体病（HGE）。患者有发热、不适和肌痛，报告有蜱叮咬史，有中度血小板减少，肝酶活性正常或略有升高。在一名患者的血液中观察到埃立克体包涵体，通过聚合酶链反应（PCR）从两名患者中均扩增出HGE病原体DNA。从基因上看，这些菌株类似于来自加利福尼亚州北部的马分离株。这两例新病例在空间和时间上的紧密接近可能是由于该地区存在感染源或当地医生加强了监测。
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