干扰CC趋化因子受体5的信号传导能力会损害其作为HIV-1进入主要T淋巴细胞时共受体的作用。 - Suppr

Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes.

作者信息

Wang J M, Oppenheim J J

机构信息

Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.

出版信息

J Exp Med. 1999 Sep 6;190(5):591-5. doi: 10.1084/jem.190.5.591.

DOI:10.1084/jem.190.5.591

PMID:10477544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195610/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a910/2195610/9a937e62aedd/JEM991002.f1.jpg

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Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes.干扰CC趋化因子受体5的信号传导能力会损害其作为HIV-1进入主要T淋巴细胞时共受体的作用。

J Exp Med. 1999 Sep 6;190(5):591-5. doi: 10.1084/jem.190.5.591.

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Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140.CCR5单克隆抗体PRO 140对1型人类免疫缺陷病毒具有强效、广谱抑制作用。

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HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.CCR5的HIV-1共受体活性及其受趋化因子的抑制作用：与G蛋白信号传导无关以及共受体下调的重要性

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Immunology. 2000 Aug;100(4):502-9. doi: 10.1046/j.1365-2567.2000.00064.x.

本文引用的文献

J Exp Med. 1999 Sep 6;190(5):597-605. doi: 10.1084/jem.190.5.597.

Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells.酪氨酸激酶激活的抑制作用可阻断HIV-1 gp120在CD4+ T细胞中对CXC趋化因子受体4的下调作用。

J Immunol. 1999 Jun 15;162(12):7128-32.

T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: implications for HIV pathogenesis.嗜T细胞的HIV gp120通过CXCR4介导CD4和CD8细胞趋化，与CD4无关：对HIV发病机制的启示。

J Immunol. 1999 May 15;162(10):6263-7.

Chemokine receptors and HIV-1: the fusion of two major research fields.趋化因子受体与人类免疫缺陷病毒1型：两个主要研究领域的融合

Immunol Today. 1999 Feb;20(2):89-94. doi: 10.1016/s0167-5699(98)01396-6.

Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5.单核细胞和巨噬细胞与HIV-1的融合与CXCR4和CCR5的生化特性相关。

Nat Med. 1999 Mar;5(3):303-8. doi: 10.1038/6523.

Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.人类免疫缺陷病毒1型感染需要百日咳毒素敏感的G蛋白偶联信号传导，并介导环磷酸腺苷（cAMP）下调。

Biochem Biophys Res Commun. 1999 Mar 16;256(2):429-35. doi: 10.1006/bbrc.1999.0333.

Chemoattractant receptor cross-desensitization.趋化因子受体交叉脱敏

J Biol Chem. 1999 Mar 5;274(10):6027-30. doi: 10.1074/jbc.274.10.6027.

HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.HIV-1包膜糖蛋白gp120通过CD4信号依赖的趋化因子受体下调抑制单核细胞对趋化因子的反应。

J Immunol. 1998 Oct 15;161(8):4309-17.

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.CD8 + T细胞的凋亡是由巨噬细胞通过HIV gp120与趋化因子受体CXCR4的相互作用介导的。

Nature. 1998 Sep 10;395(6698):189-94. doi: 10.1038/26026.

Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization.阿片类药物可使趋化因子受体发生反式失活：δ和μ阿片受体介导的异源脱敏。

J Exp Med. 1998 Jul 20;188(2):317-25. doi: 10.1084/jem.188.2.317.

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Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes.

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