Boston P F, Dennis M S, Jagger C
The Michael Carlisle Centre, Nether Edge Hospital, Sheffield, UK.
Int J Geriatr Psychiatry. 1999 Sep;14(9):761-6. doi: 10.1002/(sici)1099-1166(199909)14:9<761::aid-gps14>3.0.co;2-h.
Examination of associated factors for vascular dementia in comparison with Alzheimer's disease and a non-demented control population.
A semi-rural geographically defined population, in Melton Mowbray and the surrounding area, consisting of elderly patients aged 75 and over from a 13-doctor general practice.
438 subjects, sampled according to results of initial screening with the Mini-Mental State Examination (MMSE), were examined using the Cambridge Mental Disorders of the Elderly Examination (CAMDEX), which was also used to classify the subtypes of dementia.
34 subjects had vascular dementia, 222 had Alzheimer's disease and 140 were non-demented according to the clinician's diagnosis based on the CAMDEX criteria. Significant factors associated with vascular dementia, when compared to the Alzheimer's disease and non-demented groups, were family history of stroke and diabetes. Stroke was also significant, but this factor is one of those defining the criteria for diagnostic grouping. There were no significant differences between groups for falls, heart attack, hypertension, head injury, substance abuse or lipid levels.
The results are broadly consistent with the published literature and emphasize the importance of diabetes as a key risk factor for vascular dementia.
与阿尔茨海默病及非痴呆对照人群相比，研究血管性痴呆的相关因素。
在梅尔顿莫布雷及其周边地区一个地理界定的半农村人群，由来自一家拥有13名医生的全科诊所的75岁及以上老年患者组成。
根据简易精神状态检查表（MMSE）的初步筛查结果抽取438名受试者，采用剑桥老年精神障碍检查表（CAMDEX）进行检查，该检查表也用于对痴呆亚型进行分类。
根据基于CAMDEX标准的临床医生诊断，34名受试者患有血管性痴呆，222名患有阿尔茨海默病，140名未患痴呆。与阿尔茨海默病组和非痴呆组相比，与血管性痴呆相关的显著因素是中风家族史和糖尿病。中风也具有显著性，但该因素是诊断分组标准的界定因素之一。各组在跌倒、心脏病发作、高血压、头部受伤、药物滥用或血脂水平方面无显著差异。
结果与已发表的文献大致一致，强调了糖尿病作为血管性痴呆关键危险因素的重要性。
