Manubens J M, Martínez-Lage J M, Lacruz F, Muruzabal J, Larumbe R, Guarch C, Urrutia T, Sarrasqueta P, Martínez-Lage P, Rocca W A
Department of Neurology, University of Navarra, Pamplona, Spain.
Neuroepidemiology. 1995;14(4):155-64. doi: 10.1159/000109791.
We investigated the prevalence of dementing disorders in the city of Pamplona, Spain, using a door-to-door two-phase approach. We first administered the Cambridge Examination of Mental Disorders of the Elderly (CAMDEX) to all survivors, as of March 1, 1991, of a probability sample of the total population identified in 1989 (n = 1,127). Using specified diagnostic criteria, the study neurologists extensively investigated those subjects who screened positive on CAMDEX. We found 194 subjects affected by dementia, 119 had Alzheimer's disease; 51 vascular or mixed dementia, and 16 secondary dementia. The prevalence of both dementia and Alzheimer's disease increased steeply with advancing age and was consistently higher in women. The prevalence of combined vascular and mixed dementia increased less rapidly with age, and was generally higher in men. Alzheimer's disease was the most common type of dementia. Our prevalence figures for dementia and Alzheimer's disease are similar to those previously reported in Europe.
我们采用逐户访问的两阶段方法，对西班牙潘普洛纳市痴呆症的患病率进行了调查。我们首先对1989年确定的总人口概率样本中的所有幸存者（截至1991年3月1日，n = 1127）进行了剑桥老年精神障碍检查（CAMDEX）。根据特定的诊断标准，研究神经科医生对在CAMDEX筛查中呈阳性的受试者进行了广泛调查。我们发现194名受试者患有痴呆症，其中119人患有阿尔茨海默病；51人患有血管性或混合性痴呆，16人患有继发性痴呆。痴呆症和阿尔茨海默病的患病率均随年龄增长而急剧上升，且女性患病率始终较高。血管性和混合性痴呆合并症的患病率随年龄增长上升较慢，且男性患病率普遍较高。阿尔茨海默病是最常见的痴呆类型。我们得出的痴呆症和阿尔茨海默病患病率数据与欧洲此前报告的数据相似。
