Le Goffic F, Baca B, Soussy C J, Dublanchet A, Duval J
Ann Microbiol (Paris). 1976 Apr;127(3):391-9.
A new nucleotidyltransferase has been obtained from clinical isolates of kanamycin, amikacin, tobramycin, neomycin and lividomycin resistant strains of Staphylococcus aureus. The enzyme has been purified by affinity chromatography then characterized in a kinetic and physicochemical point of view. The results obtained support that the target of this enzyme is the 4'-hydroxyl group of a number of aminoglycosides. We propose to call it ANT(4')I.
从耐卡那霉素、阿米卡星、妥布霉素、新霉素和青紫霉素的金黄色葡萄球菌临床分离株中获得了一种新的核苷酸转移酶。该酶通过亲和层析进行了纯化，然后从动力学和物理化学角度对其进行了表征。所得结果支持该酶的作用靶点是多种氨基糖苷类药物的4'-羟基。我们建议将其命名为ANT(4')I。
