Cajochen C, Khalsa S B, Wyatt J K, Czeisler C A, Dijk D J
Circadian, Neuroendocrine and Sleep Disorders Section, Endocrine-Hypertension Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Am J Physiol. 1999 Sep;277(3 Pt 2):R640-9. doi: 10.1152/ajpregu.1999.277.3.r640.
The aim of this study was to quantify the associations between slow eye movements (SEMs), eye blink rate, waking electroencephalogram (EEG) power density, neurobehavioral performance, and the circadian rhythm of plasma melatonin in a cohort of 10 healthy men during up to 32 h of sustained wakefulness. The time course of neurobehavioral performance was characterized by fairly stable levels throughout the first 16 h of wakefulness followed by deterioration during the phase of melatonin secretion. This deterioration was closely associated with an increase in SEMs. Frontal low-frequency EEG activity (1-7 Hz) exhibited a prominent increase with time awake and little circadian modulation. EEG alpha activity exhibited circadian modulation. The dynamics of SEMs and EEG activity were phase locked to changes in neurobehavioral performance and lagged the plasma melatonin rhythm. The data indicate that frontal areas of the brain are more susceptible to sleep loss than occipital areas. Frontal EEG activity and ocular parameters may be used to monitor and predict changes in neurobehavioral performance associated with sleep loss and circadian misalignment.
本研究的目的是量化10名健康男性在长达32小时的持续清醒期间，慢眼动（SEM）、眨眼率、清醒脑电图（EEG）功率密度、神经行为表现以及血浆褪黑素昼夜节律之间的关联。神经行为表现的时间进程特点是，在清醒的前16小时内水平相当稳定，随后在褪黑素分泌阶段出现恶化。这种恶化与慢眼动增加密切相关。额叶低频脑电活动（1 - 7赫兹）随清醒时间显著增加，且昼夜调节作用很小。脑电α活动呈现昼夜调节。慢眼动和脑电活动的动态变化与神经行为表现的变化相位锁定，并滞后于血浆褪黑素节律。数据表明，大脑额叶区域比枕叶区域更容易受到睡眠剥夺的影响。额叶脑电活动和眼部参数可用于监测和预测与睡眠剥夺和昼夜节律失调相关的神经行为表现变化。
