Rotola A, Cassai E, Tola M R, Granieri E, Di Luca D
Departments of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Italy.
J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):529-31. doi: 10.1136/jnnp.67.4.529.
Studies of the association between HHV-6 and multiple sclerosis are hindered by the difficulty in discriminating between latent and active infection. A follow up study was undertaken of patients with multiple sclerosis, searching peripheral blood mononuclear cells for molecular markers associated with HHV-6 latency and lytic replication. The results show that HHV-6 is latent and did not support systemic infection in patients with multiple sclerosis. Likewise, patients with multiple sclerosis did not show any evidence of active infection with other human herpesviruses HHV-7 and HHV-8.
由于难以区分潜伏感染和活跃感染，因此对HHV - 6与多发性硬化症之间关联的研究受到了阻碍。对多发性硬化症患者进行了一项随访研究，在外周血单核细胞中寻找与HHV - 6潜伏和裂解复制相关的分子标志物。结果显示，HHV - 6处于潜伏状态，并不支持多发性硬化症患者发生全身感染。同样，多发性硬化症患者也没有表现出感染其他人类疱疹病毒HHV - 7和HHV - 8的任何活跃感染证据。
