Alvarez-Lafuente Roberto, De Las Heras Virginia, Bartolomé Manuel, García-Montojo Marta, Arroyo Rafael
Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain.
Brain Pathol. 2006 Jan;16(1):20-7. doi: 10.1111/j.1750-3639.2006.tb00558.x.
This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS).
A one-year follow up study was performed analysing peripheral blood mononuclear cells and serum samples of 57 patients with RRMS and 57 healthy blood donors (HBD) by a quantitative real time PCR, to detect HHV-6 and EBV. Clinical data (starting age and EDSS increase) were collected.
We did not find any statistically significant difference for EBV between RRMS patients and HBD. Regarding HHV-6: i) There was a higher prevalence of HHV-6 in RRMS patients than in controls: 80.7% versus 29.8% respectively. ii) HHV-6 active replication seems to be related to exacerbations. iii) Only variant A was detected among RRMS patients with HHV-6 active replication. iv) Although some difference was found when we compared clinical data in RRMS patients with and without HHV-6 active replication, the results did not reach statistical significance.
A higher HHV-6A frequency of active infection (reactivation or new infection) would lead to a more frequent exposure of HHV-6A antigens to the immune system of RRMS patients; this active replication of HHV-6A seems to be specifically related with the exacerbations in a subset of RRMS patients.
本研究旨在调查人疱疹病毒6型（HHV - 6）和爱泼斯坦 - 巴尔病毒（EBV）在复发缓解型多发性硬化症（RRMS）中的可能关系。
进行了一项为期一年的随访研究，通过定量实时聚合酶链反应（PCR）分析57例RRMS患者和57例健康献血者（HBD）的外周血单核细胞和血清样本，以检测HHV - 6和EBV。收集临床数据（起始年龄和扩展残疾状态量表[EDSS]增加情况）。
我们发现RRMS患者和HBD之间的EBV没有任何统计学上的显著差异。关于HHV - 6：i）RRMS患者中HHV - 6的患病率高于对照组：分别为80.7%和29.8%。ii）HHV - 6的活跃复制似乎与病情加重有关。iii）在HHV - 6活跃复制的RRMS患者中仅检测到A变体。iv）尽管我们比较有和没有HHV - 6活跃复制的RRMS患者的临床数据时发现了一些差异，但结果未达到统计学显著性。
更高频率的HHV - 6A活跃感染（再激活或新感染）会导致RRMS患者的免疫系统更频繁地接触HHV - 6A抗原；这种HHV - 6A的活跃复制似乎与一部分RRMS患者的病情加重特别相关。
