Melik-Musian A B, Oganesian E A, Fanardzhian V V
Laboratory of Central Nervous System Physiology, L.A. Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan.
Morfologiia. 1999;116(4):15-8.
Neurotoxic effect of 3 acetylpyridine administered in different doses to adult outbred albino rats caused morphological changes in neurons of inferior olive: nucleus translocation towards cell body periphery with central chromatolysis, cytoplasm homogenisation complete dissolution of chromatophilic substance, disappearance of cell contours with glia preservation. The most severe lesion of the nervous tissue was observed in basal olive and dorsal accessory olive in all cases studied. Majority of neurons remained unchanged in medial accessory olive and its subdivisions.
给成年远交白化大鼠施用不同剂量的3-乙酰吡啶所产生的神经毒性作用，导致下橄榄核神经元出现形态学变化：细胞核向细胞体周边移位并伴有中央性染色质溶解，细胞质均质化，嗜色物质完全溶解，细胞轮廓消失但神经胶质保留。在所研究的所有病例中，在基底橄榄核和背侧副橄榄核观察到最严重的神经组织损伤。在内侧副橄榄核及其亚区，大多数神经元保持不变。
