Zedda M, Acone F, Panu R, Farina V, Sanna L, Palmieri G
Istituto di Anatomia Normale Veterinaria Universitá di Sassari e Parma, Italy.
Ital J Anat Embryol. 1996 Jan-Mar;101(1):57-66.
The 3-Acetylpyridine (3-AP) is a neurotoxic that determines a selective destruction of inferior olivary nucleus in the rat. However, in the other animals (mouse, rabbit, guinea-pig, quail and chicken) the effect could be less selective in the mentioned nucleus and constant in other areas of the central and peripheral nervous system. This investigation means to expand the study of these neurotoxic effects to the hamster, species not yet studied. The intraperitoneal administration of 3-AP, at a dosage of 65 mg/Kg, determines in this animal stridulous breathing, coughing and ataxy. Wide sites of the nervous system show, by microscopical observations, pictures of shrinking cells, vacuolization of the cytoplasm, reduction or loss of Nissl stain affinity and neuronal mutilation. The neurotoxic effects are mostly evident in the motor nuclei of the cerebral trunk and in the ventral horns of the spinal cord. However, the inferior olivary nucleus appears undamaged or sparely involved.
3 - 乙酰吡啶（3 - AP）是一种神经毒素，可导致大鼠下橄榄核选择性破坏。然而，在其他动物（小鼠、兔子、豚鼠、鹌鹑和鸡）中，上述核团的影响可能选择性较低，而在中枢和外周神经系统的其他区域则较为恒定。本研究旨在将这些神经毒性作用的研究扩展到仓鼠，这是一种尚未研究过的物种。腹腔注射剂量为65 mg/Kg的3 - AP，可使该动物出现呼吸急促、咳嗽和共济失调。通过显微镜观察，神经系统的广泛部位显示出细胞萎缩、细胞质空泡化、尼氏染色亲和力降低或丧失以及神经元损伤的图像。神经毒性作用在脑干运动核和脊髓腹角最为明显。然而，下橄榄核似乎未受损或仅有轻微受累。
