Tapia-Arizmendi G, Feria-Velasco A
Arch Invest Med (Mex). 1980;11(2):281-94.
Intraperitoneal administration of an antimetabolite of nicotinamide, 3-acetylpyridine (3-AP) to adult rats at the dose of 65 mg/kg selectively produces lesions of the olivary nerve cells in the medulla oblongata. The neurons show progressive swelling and destruction with cell retraction, apparently by interference of energy production by means of formation of nicotinamide adenin dinucleotide analogues. Although the selectiveness of injury of olivary nerve cells to the action of 3-AP still remains unclear, the findings in the present work along with those reported in the literature reflect the existence of a regional characteristic pattern of metabolism in the various structures of the central nervous system.
以65毫克/千克的剂量向成年大鼠腹膜内注射烟酰胺的抗代谢物3-乙酰吡啶（3-AP），会选择性地导致延髓橄榄神经细胞损伤。这些神经元表现出渐进性肿胀和破坏，并伴有细胞收缩，显然是通过形成烟酰胺腺嘌呤二核苷酸类似物干扰能量产生所致。尽管橄榄神经细胞对3-AP作用的损伤选择性仍不清楚，但本研究结果以及文献报道的结果反映出中枢神经系统各结构中存在区域特征性代谢模式。
