新型隐球菌潜伏感染的流行病学证据。
Epidemiological evidence for dormant Cryptococcus neoformans infection.
作者信息
Garcia-Hermoso D, Janbon G, Dromer F
机构信息
Unité de Mycologie, Institut Pasteur, Paris, France.
出版信息
J Clin Microbiol. 1999 Oct;37(10):3204-9. doi: 10.1128/JCM.37.10.3204-3209.1999.
Abstract
To date, the time of acquisition of a Cryptococcus neoformans infectious strain has never been studied. We selected a primer, (GACA)(4), and a probe, CNRE-1, that by randomly amplified polymorphic DNA (RAPD) analysis and restriction fragment length polymorphism (RFLP), respectively, regrouped strains from control samples of C. neoformans var. grubii environmental isolates according to their geographical origins. The two typing techniques were then used to analyze 103 isolates from 29 patients diagnosed with cryptococcosis in France. Nine of the 29 patients lived in Africa a median of 110 months prior to moving to France; 17 of the patients originated from Europe. Results showed a statistically significant clustering of isolate subtypes from patients originating from Africa compared to those from Europe. We conclude that the patients had acquired the C. neoformans infectious strain long before their clinical diagnoses were made.
摘要
迄今为止，尚未对新型隐球菌感染菌株的获取时间进行过研究。我们选择了一个引物(GACA)(4)和一个探针CNRE-1，分别通过随机扩增多态性DNA(RAPD)分析和限制性片段长度多态性(RFLP)，根据其地理来源对新型隐球菌格鲁比变种环境分离株对照样本中的菌株进行重新分组。然后，使用这两种分型技术对法国29例诊断为隐球菌病的患者的103株分离株进行分析。29例患者中有9例在移居法国前在非洲生活，中位数为110个月；17例患者来自欧洲。结果显示，与来自欧洲的患者相比，来自非洲的患者的分离株亚型在统计学上有显著的聚集。我们得出结论，这些患者在临床诊断之前很久就已获得新型隐球菌感染菌株。
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