Guidotti L G, Chisari F V
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Curr Opin Microbiol. 1999 Aug;2(4):388-91. doi: 10.1016/s1369-5274(99)80068-x.
The control of viral infections was previously thought to rely exclusive ly on the antigen-specific destruction of infected cells by the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine- dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.
以前认为病毒感染的控制完全依赖于免疫系统通过抗原特异性方式破坏受感染细胞；然而，最近的研究表明，几种病毒感染可主要通过非细胞病变的、细胞因子依赖性的“治愈”机制（即病毒清除）来控制。病毒对这种治愈机制的相对敏感性不仅取决于病毒，还取决于特定受感染细胞产生适当细胞内抗病毒因子的能力。
