Ferguson M A, Gutin B, Le N A, Karp W, Litaker M, Humphries M, Okuyama T, Riggs S, Owens S
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912-3710, USA.
Int J Obes Relat Metab Disord. 1999 Aug;23(8):889-95. doi: 10.1038/sj.ijo.0800968.
To determine the effect of exercise training (ET) on components of the insulin resistance syndrome (IRS) in obese children.
Randomized, modified cross-over study, with subjects assigned to one of two conditions: (1) 4 months of ET followed by 4 months of no-ET; or (2) 4 months of no-ET followed by 4 months of ET. Measurements were made at three time points: 0, 4 and 8 months.
79 obese, but otherwise healthy children (age: 7-11 y, percent fat (%fat) 27-61%).
Plasma lipid and lipoprotein concentrations, plasma insulin and glucose concentrations; %fat; submaximal heart rate (HR) as an index of fitness. EXERCISE TRAINING: ET was offered 5 d/week 40 min/d. For the 73 children who completed 4 months of ET, the mean attendance was 80% (that is, 4 d/week) and the average HR during ET was 157 bpm.
Significant (P < 0.05) group x time interactions were found for plasma triglyceride (TG) and insulin concentrations and %fat. The average change for both groups, from just before ET to just after the 4 month ET was -0.24 mmol.l-1 for TG, -25.4 pmol.l-1 for insulin and -1.6 units for %fat. When Group 1 ceased ET, over the following 4 month period the average change for insulin was +26.6 pmol.l-1 and for %fat +1.3 units.
Some components (plasma TG, insulin, %fat) of the IRS are improved as a result of 4 months of ET in obese children. However, the benefits of ET are lost when obese children become less active.
确定运动训练（ET）对肥胖儿童胰岛素抵抗综合征（IRS）各组分的影响。
随机、改良交叉研究，受试者被分配到以下两种情况之一：（1）4个月的ET，随后4个月不进行ET；或（2）4个月不进行ET，随后4个月进行ET。在三个时间点进行测量：0、4和8个月。
79名肥胖但其他方面健康的儿童（年龄：7 - 11岁，体脂百分比（%fat）27 - 61%）。
血浆脂质和脂蛋白浓度、血浆胰岛素和葡萄糖浓度；%fat；次最大心率（HR）作为健康状况指标。运动训练：ET每周进行5天，每天40分钟。对于完成4个月ET的73名儿童，平均出勤率为80%（即每周4天），ET期间的平均心率为157次/分钟。
在血浆甘油三酯（TG）、胰岛素浓度和%fat方面发现显著的（P < 0.05）组×时间交互作用。两组从ET前到4个月ET刚结束时的平均变化，TG为 - 0.24 mmol·l-1，胰岛素为 - 25.4 pmol·l-1，%fat为 - 1.6单位。当第1组停止ET时，在接下来的4个月期间，胰岛素的平均变化为 + 26.6 pmol·l-1，%fat为 + 1.3单位。
4个月的ET可改善肥胖儿童IRS的一些组分（血浆TG、胰岛素、%fat）。然而，当肥胖儿童活动减少时，ET的益处就会丧失。
