Piérard-Franchimont C, Martalo O, Richard A, Rougier A, Piérard G E
Centre de Recherche SSTC belge 5596, Service de Dermatopathologie, Institut de Pathologie, CHU du Sart Tilman, B-4000 Liège, Belgique.
Eur J Dermatol. 1999 Sep;9(6):455-7.
Modulation of the rheological characteristics of sebum at the surface of the skin might represent a valuable strategy for the treatment of seborrhea. In this field, only a small number of studies have addressed sebum diffusion within the stratum corneum. In an open, split-face study conducted on 20 men, we measured the sebosuppressive effect of Effidrate cream which is based on a glycerol alkyl-ether. Measurements were made in the morning at three-week intervals for a total period of 3 months. Sebum casual levels and sebum excretion rates were measured using a SM810 Sebumeter. Lipid-absorbent Sebutape was also used to collect all the sebum released from infundibular reservoirs over a four-hour period. Clinical assessments were relatively uninformative but the photometric measurements showed that Effidrate cream had a sebosuppressive action. The underlying biological mechanism remains unclear but a hypothesis based on enhanced sebum absorption by the stratum corneum is discussed.
调节皮肤表面皮脂的流变学特性可能是治疗脂溢性皮炎的一种有效策略。在这一领域，仅有少数研究探讨了皮脂在角质层内的扩散情况。在一项针对20名男性进行的开放性、半脸研究中，我们测量了基于甘油烷基醚的Effidrate乳膏的皮脂抑制效果。测量在早晨进行，每隔三周进行一次，为期3个月。使用SM810皮脂测定仪测量皮脂的随机水平和皮脂分泌率。还使用脂质吸收性皮脂胶带收集4小时内从漏斗状皮脂腺中释放的所有皮脂。临床评估提供的信息相对较少，但光度测量表明Effidrate乳膏具有皮脂抑制作用。其潜在的生物学机制尚不清楚，但讨论了一种基于角质层对皮脂吸收增强的假说。
