Piérard G E, Piérard-Franchimont C
Department of Dermatopathology, University of Liège, Belgium.
Clin Exp Dermatol. 1993 Sep;18(5):410-3. doi: 10.1111/j.1365-2230.1993.tb02238.x.
Zinc displays 'in vitro' some antiandrogen activity through an inhibition of the 5 alpha-reductase activity. The clinical relevance of this effect is unknown, particularly during zinc therapy of acne. As sebum production could be a pharmacological target, a sensitive method was used for measuring the rate of sebum delivery to the skin surface during treatment with a topical 4% erythromycin-1.2% zinc acetate formulation. A series of four successive 1-h samplings with Sebutape was taken to derive the rate of sebum output from the slope of the regression line given by cumulative data. As a control the classical photometric method was used. Such combined evaluation revealed a sebosuppressive effect for the topical zinc formulation tested.
锌在体外通过抑制5α-还原酶活性表现出一定的抗雄激素活性。这种作用的临床相关性尚不清楚，尤其是在痤疮的锌治疗过程中。由于皮脂分泌可能是一个药理学靶点，因此使用一种灵敏的方法来测量在用4%红霉素-1.2%醋酸锌局部制剂治疗期间皮脂输送到皮肤表面的速率。使用皮脂胶带进行了一系列连续4次1小时的采样，以根据累积数据的回归线斜率得出皮脂分泌速率。作为对照，使用了经典的光度法。这种综合评估揭示了所测试的局部锌制剂具有抑制皮脂分泌的作用。
