沙眼衣原体热休克蛋白10的血清学调查
Serological investigation of Chlamydia trachomatis heat shock protein 10.
作者信息
Betsou F, Sueur J M, Orfila J
机构信息
Biobanque de Picardie, University Hospital, Amiens, France.
出版信息
Infect Immun. 1999 Oct;67(10):5243-6. doi: 10.1128/IAI.67.10.5243-5246.1999.
Abstract
The humoral immune response to Chlamydia trachomatis 10-kDa heat shock protein (Chsp10) in populations of Russian and French origin was studied by using a recombinant Chsp10 enzyme-linked immunosorbent assay. A physiological but not a serological correlation of Chsp10 exposure with Chsp60 exposure was observed in the Russian population. In the French population studied, there was a significant association between detection of anti-r-Chsp10 immunoglobulin G (IgG) antibodies and chronic genital tract infections. Chsp10 residues 50 to 67 were found to contain an immunodominant although not universal B epitope. Cross-reactions with Chlamydia pneumoniae or Escherichia coli GroES protein are limited but may occur. Our study suggests that detection of anti-Chsp10 IgG antibodies is associated with chronicity of C. trachomatis genital tract infection and does not parallel that of anti-Chsp60 IgG antibodies.
摘要
采用重组沙眼衣原体10-kDa热休克蛋白（Chsp10）酶联免疫吸附试验，研究了俄罗斯和法国人群对沙眼衣原体10-kDa热休克蛋白（Chsp10）的体液免疫反应。在俄罗斯人群中观察到Chsp10暴露与Chsp60暴露存在生理而非血清学相关性。在所研究的法国人群中，抗重组Chsp10免疫球蛋白G（IgG）抗体检测与慢性生殖道感染之间存在显著关联。发现Chsp10的50至67位残基含有一个免疫显性但并非普遍存在的B表位。与肺炎衣原体或大肠杆菌GroES蛋白的交叉反应有限，但可能会发生。我们的研究表明，抗Chsp10 IgG抗体的检测与沙眼衣原体生殖道感染的慢性化有关，与抗Chsp60 IgG抗体的检测情况并不平行。
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