Schoeller D A
Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA.
J Nutr. 1999 Oct;129(10):1765-8. doi: 10.1093/jn/129.10.1765.
The doubly labeled water (DLW) method was developed 50 years ago, but nearly 40 years passed before it became a major tool for human nutrition research. Its use has grown dramatically, however, since the first human applications. The DLW method is now the preferred method for determining energy requirements of healthy and clinical populations. The method has been applied extensively to the study of the growing problem of obesity in order to determine the role of energy expenditure and physical activity in weight control. Finally, DLW has provided a new means of validating methods for assessing dietary intake. The accuracy and noninvasive nature of the DLW method makes it ideal for the study of human energy metabolism.
双标水（DLW）法是50年前开发的，但在近40年后它才成为人类营养研究的主要工具。然而，自首次应用于人体以来，其应用量急剧增长。DLW法现在是确定健康人群和临床人群能量需求的首选方法。该方法已广泛应用于日益严重的肥胖问题研究，以确定能量消耗和身体活动在体重控制中的作用。最后，DLW为验证评估膳食摄入量的方法提供了一种新手段。DLW法的准确性和非侵入性使其成为研究人体能量代谢的理想方法。
