Rovaris M, Filippi M
Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
Curr Opin Neurol. 1999 Jun;12(3):337-44. doi: 10.1097/00019052-199906000-00012.
Although the correlations between magnetic resonance findings and long-term disease evolution range from poor to moderate, conventional precontrast and postcontrast magnetic resonance imaging provides sensitive and reliable measures to monitor multiple sclerosis activity over time. New pulse sequences with shorter acquisition times can be cost effective and reduce patients' discomfort. The application of other techniques that give more accurate estimates of disease burden and have higher pathological specificity might improve our understanding of multiple sclerosis evolution and provide new outcomes for monitoring clinical trials. Work is still needed to obtain optimal imaging of the spinal cord for multiple sclerosis diagnosis and monitoring.
尽管磁共振成像结果与疾病长期演变之间的相关性从较差到中等不等，但传统的对比前和对比后磁共振成像提供了敏感且可靠的方法来长期监测多发性硬化症的活动情况。采集时间更短的新脉冲序列可能具有成本效益，并能减轻患者的不适。应用其他能更准确估计疾病负担且具有更高病理特异性的技术，可能会增进我们对多发性硬化症演变的理解，并为监测临床试验提供新的结果。在获取用于多发性硬化症诊断和监测的脊髓最佳成像方面仍需开展工作。
