Filippi M
Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
J Neurol Neurosurg Psychiatry. 1998 May;64 Suppl 1:S52-8.
Conventional magnetic resonance imaging (MRI) techniques have proved to be extremely useful to monitor multiple sclerosis activity and evolution. The recent development and clinical application of non-conventional MR techniques has the potential to further increase the importance of MR in the evaluation of multiple sclerosis by reducing the time needed for acquisition of the data, by improving sensitivity, and by increasing the pathological specificity of the abnormalities detected. In the present review, the main results obtained using these newer techniques in the study of the natural history of the disease and the future possible applications in clinical trials are presented.
传统的磁共振成像（MRI）技术已被证明在监测多发性硬化症的活动和进展方面极为有用。非常规MR技术的最新发展和临床应用有可能通过减少数据采集所需时间、提高敏感性以及增强所检测异常的病理特异性，进一步提升MR在评估多发性硬化症中的重要性。在本综述中，介绍了使用这些较新技术在疾病自然史研究中获得的主要结果以及在临床试验中的未来可能应用。
