Shu S Y, Bao X, Li S, Niu D, Xu Z, Li Y
Department of Neurobiology, Institute for Neuroscience of the First Military Medical University, Zhu-Jiang Hospital, First Military Medical University, Guangzhou, China.
J Neurosci Res. 1999 Oct 15;58(2):242-53.
A new subdivision with distinctive morphological and functional attributes has been identified at the caudomedial margin of the neostriatum and surrounding the rostrolateral border of the globus pallidus in the brains of the rat, cat, monkey, and human. The subdivision is termed marginal division (MrD) based on its location. It is readily distinguishable from the rest of striatum by consisting of spindle-shaped neurons, special connections, and intensely expressed immunoreactivities of many neuropeptides and some monoamines in the fibers, terminals, and neuronal somata. Three-dimensional reconstruction from Nissl-stained sections of the rat brain revealed that the MrD is a flat, pan-shaped zone between the neostriatum and globus pallidus. Functional neuronal connections were delineated by chemical-induced c-Fos expression between the MrD and hippocampus, amygdala, as well as the basal nucleus of Meynert. In rats with chemical lesions of bilateral MrD, learning and memory functions were severely impaired as demonstrated by double blind Y-maze test. Our results thus suggested that the MrD is a distinct part and a universal structure in the neostriatum of the mammalian brain and might play an important role in the mechanism of learning and memory.
在大鼠、猫、猴和人类大脑中，已在新纹状体的尾内侧边缘以及围绕苍白球的嘴外侧边界处识别出一个具有独特形态和功能特征的新分区。根据其位置，该分区被称为边缘区（MrD）。它很容易与纹状体的其他部分区分开来，因为它由梭形神经元、特殊连接以及纤维、终末和神经元胞体中许多神经肽和一些单胺的强烈免疫反应性组成。对大鼠脑尼氏染色切片进行的三维重建显示，MrD是新纹状体和苍白球之间的一个扁平的盘状区域。通过化学诱导的c-Fos表达描绘了MrD与海马体、杏仁核以及Meynert基底核之间的功能性神经元连接。在双侧MrD化学损伤的大鼠中，双盲Y迷宫试验表明学习和记忆功能严重受损。因此，我们的结果表明，MrD是哺乳动物脑新纹状体中的一个独特部分和普遍结构，可能在学习和记忆机制中起重要作用。
